Pharmaceutical peptide publications

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Thymogen patents (expired)

  1. Yakovlev G.M., Morozov V.G., Khavinson V.H., Deigin V.I., Korotkov A.M. “Immunomodulatory Preparation “Thymogen”. Patent Russian Federation №1582393. Priority Date 30.12.87

  1. Yakovlev G.M., Morozov V.G., Khavinson V.H., Deigin V.I., Korotkov A.M. “Pharmaceutical Preparation for the Therapy of Immunodeficiency Conditions”. Patent Australia №616236. Priority Date 30.12.87.

  1. Yakovlev G.M., Morozov V.G., Khavinson V.H., Deigin V.I., Korotkov A.M. “Pharmaceutical Preparation for the Therapy of Immunodeficiency Conditions”. Canadian Patent № 13330300. Priority Date 30.12.87.

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Deigin V.I., Iarova E. P. “Peptide, a Method for Its Preparation and a Pharmaceutical Composition Containing the Peptide (Sedatin)”. European Patent # 779076. Priority Date 29.06.1994

Deigin V.I., Iarova E. P. “Peptide, a Method for Its Preparation and a Pharmaceutical Composition Containing the Peptide (Sedatin)”. Canadian Patent # 2,193,969. Priority Date 29.06.1994

Deigin V.I., Iarova E. P. “Peptide, a Method for Its Preparation and a Pharmaceutical Composition Containing the Peptide (Sedatin)”. USA Patent # US 6,184,208 B1. Priority Date 29.06.1994

Bobkova N. V., Plakhinas L. A., Deigin V. I., Iarova E. P., Iarov A. V. “ Preparation for Lowering of Alcohol Dependence”. Patent Russian Federation №2050856. Priority Date 12.02.1992.

Deigin V. I., Baturina E. Yu., Kamensky A. A., Iarova E. P. “Peptide with analgesic activity”. Patent Russian Federation № 2040272. Priority Date 15.04.1993.

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Patent platform related to Stvologen

  1. Deigin V.I. “Branched piperazin-2,5-dion derivatives (2,5-DKP) of peptides and small molecules”. PCT: “Multifunctional Bioactive Compounds”. WO 2008/014613 -1- PCT/CA2007/001357.

  2. Deigin V.I. “Multifunctional bioactive compounds”. European Patent # 2046778.

Priorities Date 01.08.2007.

  1. Deigin V.I. “Multifunctional bioactive compounds”. Canadian Patent # 2,659,875.

Priorities Date 01.08.2007.

  1. Deigin V.I. “Substituted Piperazin-2,5-diones As multifunctional Bioactive Compounds”. USA Patent #9,108,931B2. Priorities Date 01.08.2007.

  2. Deigin V.I. “Multifunctional bioactive compounds”. Eurasian Patent # 018548. Priorities Date 01.08.2007.

  3. Deigin V.I. “Multifunctional bioactive compounds”. Australian Patent # 2007280995 B2. Priorities Date 04.08.2006.

  4. Deigin V.I. “Substituted Piperazin-2,5-diones and their use as multifunctional Bioactive Compounds”. USA Patent #8,637,521 B2. Priorities Date 01.08.2007.

Peer–Reviewed Publications (Selected):

1. Ulyashin V.V., Deigin V.I., Ivanov V.T., Ovchinnikov Yu.A. “High–Performance Size–Exclusion Chromatography of Protected Peptides.” J.Chromatography–1981.–v.215.–p.263–277.

2. Deigin V.I., Ulyashin V.V., Mikhaleva I.I., Ivanov V.T. “Total Synthesis of Neurotoxin II from the Central Asian (Naja Naja Oxiana) Venom.” In “Peptides.–1982”.–(K.Blaha ed.).Walter de Gruyter.– Berlin–New–York.–1983.–p.277–283

3. Ulyashin V.V., Deigin V.I. “High Performance Liquid Chromatography of Protected Peptides.” In Chemistry of Peptides and Proteins.-Walter de Gruyter.–Berlin New–York.–1983.–v.2.–p.145–153

4. Deigin V.I., Yarova E.P. “Synthesis of Dermorphin and Its Analogs.” In “Peptides.–1984” (U.Raggnarsson, ed).–Stockholm.–1984.–p.325–328.

Bespalova Z.D., Pekelis B.L., Deigin V.I. “Synthesis and Evaluation of Antigenic Properties of the HIV–1. Protein GR–41.” Collection Czechoslovak of Chemical Communication.–1990.–v.55.–№10.- p.2537–2554

6. Khemelnitsky O.K., Yakovlev G.M., Belyanin V.I., Deigin V.I. “Thymogen (Synthesis Thymic Peptide) Effect on the Immune System Under Conditions of Immune–deficiency in Candidasis.” Archive of Patology.–1990.-№1.–p.20–25

7. Emel’ynova T.G., Usenko A.B., Kamenskii A.A., Deigin V.I., Yarova E.P. “Effects of Dermorphine on Thermoregulation.” Biomed. Sci.–1991.–v.2.–№6.–p.601-606

8. Semina O.V., Semenets T.N., Deigin V.I., Korotkov A.M., Poverenny A.M. “Effect of the Peptide of Thymus Origin (synthetic thymohexine–RKNVYR) on Hemopoietic Cell Progenitors in Intact and Irradiated Animals.” Immunology Letters.–1996.–v.51.-№3.–p.137–140.

  1. Emel’yanova T.G., Usenko A.B., Deigin V.I., Yarova E.P., Kamensky A.A. “Effect of Dermorphin on Thermoregulation in Rats at Selected Ambient Temperatures.” Peptides.–1996–v.17.–p.241–245

Deigin V.I., Poverenny A.M., Semina O.V., Semenets T.N. “Reciprocal Effect of Optical Isometrism of EW–dipeptides on Immune Response.” Immunology Letters.–1999.–v.67.-№1.–p.41–46

10. Deigin V.I., Semenets T.N., Zamulaeva I.A., Maliutina Ya.V., Selivanova E.I., Saenko A.S., Semina O.V. “The Effects of the EW Dipeptide Optical and Chemical Isomers on the CFU–S Population in Intact and Irradiated Mice.” International Immunopharmacology.– 2007.–v.7.–p.375–382

11. Deigin V. “Branched Diketopiperazines as Universal Scaffold for Preparation of Orally Active Small Peptide Derivatives.” Biopolymers.–2011.- v.96.–issue 4.–p.470

12. V.Deigin, O. Ksenofontova, A. Khrushchev, Oleg Yatskin, A. Goryacheva, V.Ivanov “Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity” ChemMedChem, 2016,11,p.1–5

13. Deigin V, Ksenofontova O, Yatskin O, Kublitsky V, Shmygarev V, Abramovich R, Dubinnyi M, Ivanov V. “ Novel side reaction accompanying cyclization of Glu(R1)–Glu(R2) dipeptides via lactamization of the Glu(R1) residue”. J Pept Sci. 2018 Jun;24(4–5), p 3074. doi: 10.1002/psc.3074.

14. O.A. Belozerova , V.I. Deigin, A.Yu. Khrushchev , M.A. Dubinnyi, V.S. Kublitski “The total synthesis of sevanol, a novel lignan isolated from the thyme plant (Thymus armeniacus)/Tetrahedron, 74 (2018) 1449–1453.

15. Volpina О., Volkova T., Kamynina A., Deigin V,Bobkova N. (2015). Protective activity of the prion protein fragment at immunization of animals with induced Alzheimer disease. Bioorganic Chem. (Russia) v 41(2), p145–153.

16. Deigin, V.; Ksenofontova, O.; Yatskin, O.; Goryacheva, A.; Ignatova, A.; Feofanov, A.; Ivanov, V. Novel platform for the preparation of synthetic orally active peptidomimetics with hemoregulating activity. II. Hemosuppressor activity of 2, 5-diketopiperazine-based. Int. Immunopharmacol. 2020, 81, 106185, doi:https://doi.org/10.1016/j.intimp.2020.106185.

17.Deigin, V.; Ksenofontova, O.; Khrushchev, A.; Yatskin, O.; Goryacheva, A.; Ivanov, V. Chemical Platform for the Preparation of Synthetic Orally Active Peptidomimetics with Hemoregulating Activity. ChemMedChem 2016, 1974–1977, doi:10.1002/CMDC.201600157.

18. Deigin, V.I.; Vinogradova, Y.E.; Vinogradov, D.L.; Krasilshchikova, M.S.; Ivanov, V.T. Thymodepressin—Unforeseen Immunosuppressor. Mol. 2021, Vol. 26, Page 6550 2021, 26, 6550, doi:10.3390/MOLECULES26216550.

19. Deigin, V.I.; Poluektova, E.A.; Beniashvili, A.G.; Kozin, S.A.; Poluektov, Y.M. Development of Peptide Biopharmaceuticals in Russia. Pharmaceutics 2022, 14, 716. https://doi.org/10.3390/ pharmaceutics14040716.

Conferences (Selected):

1. Ivanov V.T., Mikhaleva I.I., Volpina O.M., Deigin V.I. “Synthesis of Protected –Bungarotoxin”. Proc. of the 14th European Peptide Symposium.–Belgium.–1976.–p.219–231.

2. Mikhaleva I.I., Deigin V.I., Ulyashin V.V., Ivanov V.T. “Synthesis of Fragments of Neurotoxin II from the Naja Naja Oxiana Venom and Their Purification by High–performance Liquid Chromatography” Proceedings of 15th European Peptide Symposium. Peptides.–1978.–(I.Z.Semion, Kypryszewski ed.).– Wrozlaw.–University Press.–1979.–p.391–395

3. Deigin V.I., Mikhaleva I.I., Ulyashin V.V., Ivanov V.T. “Synthetic Studies of Neurotoxin II from the Venom of Central Asian Cobra Naja Naja Oxiana.” III USSR-FRG Symposium on Chemistry of Peptides and Proteins.–Makhachkala.–Abstr.–1980.–p.60

4. Ulyashin V.V., Deigin V.I., Mikhaleva I.I., Ivanov V.T. “Size-exclusion HPLS as a Novel Tool in Peptide Synthesis.” 7th American Symposium.-Wisconsin.–Abstr.–1981.–p.130

5. Deigin V.I., Ulyashin V.V., Mikhaleva I.I., Ivanov V.T. “Total Synthesis of Neurotoxin II from the Venom of Central Asian Cobra Naja Naja Oxiana.” Abstract. 17th European Peptide Symposium.–Prague.- 1982.–p.42

6. Deigin V.I., Yarova E.P. “Synthesis of Dermorphin and its Analogs.” Peptides.–1984.–Proc. of the 18th European Peptide Symposium.–(U.Raggnarsson, ed).–Stockholm.–1984.–p.325–328.

7. Deigin V.I., Ulyashin V.V. “Synthetic Neurotoxin II from the Naja naja oxiana Central Asian Cobra Venom. Physicochemical Characterization.” 16th Meeting of the Federation of European Biochemical Societies.–Moscow.–Abstr.–1984.–p.327

8. Deigin V.I., Makarov E.A., Yurovski V.V., Rar V.A. “Design and Synthesis of Highly Immunogenic Peptide Preparations.” 9th American Peptide Symposium.–Toronto.–Abstr.–1985.–p.136

9. Deigin V.I., Pomogaibo S.V., Korotkov A.M., Sepetov N.F., Titov M.I. “Synthetic Studies of alfa–1- thymosin.” Proc. of VI FRG–USSR Symposium on Chemistry of Peptides and Proteins.-Hamburg.–1987.- p.12

10. Vinogradova Yu.E., Zamulaeva I.A., Selivanova E.I., Deigin V.I., Saenko A.S. “Diagnostics of B– cellular Lymphoid Leukemia Using Two–color Flow Cytofluorometry.” Abstract of VII International Conference on Malignant Lymphoma.–Lugano.–Switzerland.–1999.–p.321

11. Deigin V.I., Poverenny A.M., Semina O.V., Semenets T.N. Stimulation and Suppression of the Immune Response and Hemopoiesis by the Novel Natural and Synthetic Peptides.” Abstract of 16th American Peptide Symposium.–Minneapolis.–Abstr.–1999.–p.319

12. Deigin V.I., “From Immunomodulator Thymogen to Immunosuppressant Thymodepressin. Experimental and Clinical data.” Abstract of First Int. Russian Peptides and Proteins Symposium.– Moscow.–2003.–p.43

13. Krasilzhikova M.S., Zatsepina O.V., Deigin V.I. “Protective Effect of Thymodepressin in Experimental Autoimmunity.” Abstract of 6th International Congress on Autoimmunity.–Porto.–2008.p.29

14. V.Deigin. New Platform Technology for Preparation of Orally Active Small Peptide Derivatives: The Use of Diketopiperazines as The Universal Scaffold. Abstracts.–21st American Peptide Symposium.– Bloomington.–Indiana.-USA.–June 7–12–2009.–p.363

15. Deigin V,I, “Cyclotechnology. The Novel Approach to Orally Active Small Peptide and Peptidomimetic Derivatives.” Abstract of 4th Int. Russian Peptides and Proteins Symposium.–Kazan.- 2009.–p.102

16. Luzyanina A.A., Shevchenko A. A., Semin Yu. A. Deigin V.I. “Influence of Thymodepressin on the Grows and Metastasis of Experimental Tumors.” Abstract of III Int. Symposium “BIOPHARMA 2011”. Israel, Tel–Aviv. P.19–20.

17. Deigin V.I., Ksenofontova O. B., et. al. “Influence of Chemical and Optical Structure on Biological Activity of Short Peptides and 2,5–diketopiperazne Derivatives.” Abstract of 5th Int. Russian Peptides and Proteins Symposium.–2011.Petrozavodsk, p.139

18. Deigin V. “Two Reciprocal Therapeutics from One EW–peptide Family.” 5th International Congress Natural Peptides to Drugs.–Zermatt.–Switzerland.–Abstracts.–2011.–p.113.

19. Deigin V. “Branched Diketopiperazines as a Universal Scaffold for Preparation of Orally Active Small Peptide Derivatives.” 32th European Peptide Symposium.–Athens.–Greece.–Proceedings.– 2012.–p.36–37

20. Deigin V. “Orally Active Peptidomimetics Based on Branched 2,5–diketopiperazines: Structure- Functional Studies”. 33th European Peptide Symposium. Journal of Peptide Science.– Sofia.–2014.–v.20.- Issue S1.– p.50

21. Deigin V. I. Ksenofontova O. B. et. al. “Structure– Functional Studies of Orally Active Peptidomimetics Based on the 2,5–diketopiperazines.” Abstract of 7th Int. Russian Peptides and Proteins Symposium.” Novosibirsk, Russia – 2015. – p.50

22. V. Deigin. “Orally Active Peptidomimetics Based on Branched 2,5–Diketopiperazines”. Abstract of 18th TIDES–2015 Symposium. San Diego CA. – USA. – P6.

23. Deigin V. Novel branched diketopiperazines as a universal scaffold for orally active small peptide derivatives // Journal of peptide science. – 2016. – V.22. – Issue 52. – P. 98–99. IF: 1,951. Q 2.

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